Terrence Gavin, Ph.D.
Email: tgavin@iona.edu
EDUCATION
| 1982 | Ph.D. |
Organic Chemistry Thesis "The Synthesis of Oligonucleotides via Cyclic Enediol Phosphates"; Advisor: Prof. Fausto Ramirez |
| 1977 | M.S. |
Organic Chemistry
State University of New York, Stony Brook |
| 1971 | B.S. | Chemistry State University of New York, New Paltz |
APPOINTMENTS
| 2003-present | Department of Chemistry, Iona College, New Rochelle, NY |
| 1999-present | Chair, Department of Chemistry, Iona College, New Rochelle, NY |
| 1989-2003 | Associate Professor of Chemistry, Iona College |
| 1986-1992 | Chair, Department of Chemistry, Iona College |
| 1982-1989 | Assistant Professor of Chemistry, Iona College |
| 1995 | Adjunct Lecturer, State University of New York, New Paltz |
| 1977-1979 | Associate Scientist, CIBA-Giegy Corp., Ardlsey, NY |
TEACHING INTERESTS
Interests: Organic Chemistry (all levels), Heterocyclic Chemistry, General Chemistry, Science/Technological Literacy. Courses Taught: Organic Chemistry I-II, Organic Chemistry Laboratory I-II (micro-scale and semi-micro/macro-scale) Chemical Synthesis Laboratory, Advanced Organic Chemistry, General Chemistry I-II, General Chemistry Laboratory I-II, Chemical Literature Seminar, Chemistry Capstone Seminar, Instrumental Methods, Biochemistry I-II, Scientific and Technological Literacy, Nutrition, Physical Science (for graduate programs in Elementary education).
RESEARCH INTERESTS
Studying the underlying causes of the neurotoxicity elicited by certain environmental pollutants and attempting to relate the results of these studies to an more comprehensive understanding of neurodegenerative diseases that occur in humans (e.g., ALS, Alzheimer’s, Parkinson’s Disease etc.).
Characterization of toxic chemical electrophiles using HSAB parameters.
Synthetic methods related to the chemistry of aromatic and hetreocyclic compounds.
Applications of computational methods to chemical education.
PUBLICATIONS
1. LoPachin, R.M., Gavin, T., Geohagen, B.C., Zhang, L., Casper, D., Lekrhaj, R., and Barber, D.S.,“β-Dicarbonyls Enolates: A New Class of Neuroprotectants”. Journal of Neurochemistry. (Submitted)
2. Zhang, L., Gavin, T., Barber, D.S. and LoPachin, R.M., “Expression of Antioxidant and Phase II Enzymes in Acrylamide Neurotoxicity”, NeuroToxicology 2010. (Submitted)
3. Zhang, L., Gavin, T., DeCaprio, A.P. and LoPachin, R.M., “γ-Diketone Neuropathy: Analysis of Cytoskeletal Motors and Highways in CNS Axons”, Toxicol. Sci. 2010, 117, 180-189.
4. Lopachin, R.M.; Gavin, T.; Petersen, D. R.; Barber, D. S., “Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation”, Chem. Res. Toxicol. 2009, 22, 1499-1508.
5. Lopachin, R.M.; Geohagen, B. C.; Gavin, T., “Synaptosomal Toxicity and Nucleophillic Targets of 4-Hydroxy-2-Nonenal”, Toxicol. Sci. 2009, 107, 171-181.
6. Lopachin, R.M.; Gavin, T., “Acrylamide-Induced Nerve Terminal Damage: Relevance to Neurotoxic and Neurodegenerative Mechanisms”, J. Agric. Food Chem. 2008, 56, 5994-6003.
7. Lopachin, R. M.; Gavin, T.; Barber, D. S., “Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases” NeuroToxicology 2008, 29, 871-882.
8. Lopachin, R.M.; Barber, D.S.; Gavin, T., “Molecular Mechanisms of the Conjugated Unsaturated Carbonyl Derivatives: Relevance to Neurotoxicity and Neurodegenerative Diseases”, Toxicol. Sci. 2008, 104, 235-249.
9. LoPachin, R.M; Gavin, T.;.Geohagen, B.C.; Das, S., “Neurotoxic Mechanisms of Electrophillic Type-2 Alkenes: Soft-Soft Interactions Described by Quantum Mechanical Parameters”, Toxicol. Sci. 2007, 98, 561-570.
10. LoPachin, R.M.; Barber, D.S.; Geohagen, B.C.; Gavin, T.; Das, S.; He, D., “Structure Toxicity Analysis of Type-2 Alkenes: In Vitro Neurotoxicity”, Toxicol. Sci. 2007, 95, 136-146.
11. Smith, R.A.; Nescawicz, A.; Gavin, T; Salvatore, R.N., “Mild, Efficient and Highly Chemoselective Alkylation of Thiols Using Cs2CO3”, Tetrahedron Lett. 2005, 46, 8931-8935.
12. McKinney, A. M., Jackson, K. R., Salvatore, R.N., Savrides, E-M., Edattel, M.J., Gavin, T., “A Rapid and Efficient Method for the Reduction of Quinoxalines”, J. Heterocyclic Chem. 2005, 42, 1031-1034.
13. Gavin, T., “Quantitative Thermodynamic Descriptions of Aromaticity”, J. Chem. Educ. 2005, 82, 953-958.
14. Novak, R.; Gavin, T., “Teaching about Lead in the Environment”, Bulletin of Science, Technology and Society, 1988, 8, 424.
15. Watthey, J.W.; Gavin, T.; Desai, M., “Bicyclic Lactam Inhibitors of Angiotensin Converting Enzyme”, J. Med. Chem. 1984, 27, 816-818.
16. Ramirez, F.; Gavin, T.E.; Mandel, S.B.; Kelkar, S.V.; Marecek, J.F., “Synthesis of Deoxribotetranucleotides by the Cyclic Enediol Phosphorylation Method” Tetrahedron 1983, 39, 2157-2161.
17. Watthey, J.W.; Gavin, T.; Desai, M.; Finn, B.; Rodebaugh, R.K.; Patt, S., “Synthesis and Biological Properties of Thiophene Ring Analogues of Mianserin”, J. Med. Chem. 1983, 26, 1116-1122.
TEXTS
- Gavin, Terrence (one of 12 co-authors), Laboratory Manual to Accompany The Sciences An Integrated Approach, 2nd ed., Stanionis, V. (editor), John Wiley & Sons, Inc., New York, 1998.
PRESENTATION/POSTERS
- McKinney, A. M.; Jackson, K. R.; Poppy, D. C.; Smith, A. M.; Salvatore, R.N., Savrides, E-M., Edattel, M.J., Gavin, T., “A Rapid and Efficient Method for the Reduction of Nitrogen Heterocycles”, Division of Organic Chemistry (Poster), 230th ACS National Meeting 2005.
- Smith, R.A.; Nescawicz, A.; Gavin, T; Salvatore, R.N. “A Mild, Efficient and Highly Chemoselective Alkylation of Thiols Using Cs2CO3 and TBAI”, Division of Organic Chemistry (Poster), 228th ACS National Meeting 2004.
- Pomerantz, J.; Matarlo, J.; Gavin, T., “Reduction of Quinoline with Borane” NY Chemistry Students’ Association 55nd Annual Undergraduate Research Symposium, 2007.
- Pomerantz, J.; Gavin, T., “Intra-annular vs Extra-annular Diels-Alder Reactions of 3,3’-Bifuran: A Computational Study” NY Chemistry Students’ Association 53nd Annual Undergraduate Research Symposium, 2005.
- Savrides, E-M.; Gavin, T., “Borohydride Reduction of Quinoxalines”, NY Chemistry Students’ Association 52nd Annual Undergraduate Research Symposium, 2004.
- Bean, D.; Bravo, A.H.; Gavin, T., “Reactions of N-Methyl-2-Arylquinoxalinium Salts”, NY Chemistry Students’ Association 50th Annual Undergraduate Research Symposium, 2002.
- Coppola, J. M., Gavin, T., “A Convenient Synthesis of 3,4-Dihydroxyphenyl acetaldehyde (DOPAL)”, NY Chemistry Students’ Association 49th Annual Undergraduate Research Symposium, 2001.
- Edattel, M.J.; Gavin, T., “Reactivity of 2-Arylquinoxalines”, NY Chemistry Students’ Association 48th Annual Undergraduate Research Symposium, 2000.
PATENTS
U.S. Provisional Patent Application (2010), “Methods and Compositions for Treating Conditions Mediated by Oxidative Stress or Electrophilic Environmental Toxins”, R. M. LoPachin and T. Gavin.
GRANTS AND AWARDS
- “Incorporation of FT-NMR into the Undergraduate Curriculum”, National Science Foundation, Division of Undergraduate Education, Course, Curriculum and Laboratory Improvement Grant- 2002-2003
- “UV-Visible Spectroscopy for Undergraduates in Biology and Chemistry”, The Josephine Lawrence Hopkins Foundation, 2002
- “Using Molecular Modeling and Computational Chemistry Software in Introductory Chemistry Courses”, Faculty Innovative Technology Award, Iona College, 2001
- “Pro Operis” Award, Iona College, 2002
- New York State Regents Scholarship, 1966
COLLABORATIVE GRANTS
- “1,3-Dicarbonyl Enols: A New Class of Cytoprotectants” National Institute of Environmental Health Sciences with Richard M. LoPachin (PI) 2010. (pending)
- “Nerve Terminal as a Site of Action for Type-2 Alkenes” National Institute of Environmental Health Sciences with Richard M. LoPachin (PI) 2008-2012.
- “Molecular Mechanism of Hexacarbon Induce Axon Atrophy” National Institute of Environmental Health Sciences with Richard M. LoPachin (PI) 2006-2010.
PROFESSIONAL DEVELOPMENT
- “Molecular Modeling Using SPARTAN Software”, one day workshop sponsored by Wavefunction, Inc., Manhattan College, New York, N.Y., 2001
- “The Microscale Organic Laboratory”, five day workshop sponsored by ACE Glass, Inc., University of West Virginia, Morgantown, W.Va., 1998
- “Advanced NMR Techniques” summer workshop (five weeks) sponsored by the National Science Foundation, Rensselaer Polytechnic Institute, Troy, N.Y., 1992
- “Modern NMR Concepts and Applications” short course sponsored by the New York Section of the American Chemical Society, Technicon Instruments Division, Tarrytown, N.Y., 1987
- “Operation and Applications of the Varian EM-390 NMR Spectrometer” one day workshop sponsored by the Varian Corp., Florham Park, N.J., 1977
INVITED LECTURE
- “Quantitative Thermodynamic Descriptions of Aromaticity: Computational Exercises for the Organic Chemistry Laboratory”, University of Massachusetts, Boston MA 2006.
- “Aromatic Heterocycles: New Reactions, New Compounds, New Concepts”, Appalachian State University, Boone NC 2006.
- “Quantitative Thermodynamic Descriptions of Aromaticity: Computational Exercises for the Organic Chemistry Laboratory”, Kennesaw State University, Kennesaw GA 2006.
- “Aromaticity and Electrophillic Aromatic Substitution”, Marist College, Poughkeepsie NY 2004.
REVIEWS
Ad Hoc reviewer for Journal of Chemical Education, Journal of Undergraduate Chemical Research and Synthetic Letters, the Research Corporation and Department of Defense
· CHM209 Organic Chemistry I
o Syllabus (Fall 2010)
· CHM220 Organic Chemistry Laboratory
o Syllabus (Fall 2010)
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